MHC Class II Genes in Mexican Patients with Idiopathic Dilated Cardiomyopathy

Abstract:

The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC = 0.02, OR = 1.87), HLA-DQB1*0301 (pC = 0.02, OR = 1.92) and HLA-DQB1*0302 (pC = 0.02, OR = 1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC = 0.03, OR = 0.26) and HLA-DQB1*0201 (pC = 0.04, OR = 0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.