MHC Class II Genes in Mexican Patients with Idiopathic Dilated Cardiomyopathy


Rodríguez-Pérez, José Manuel; Fragoso, Jose Manuel; Alvarez-León, Edith; Martínez-Rodríguez, Nancy; Gallardo, Guillermo J.; Inés-Real, Selene; Granados, Julio; Reyes, Pedro A.; Vargas-Alarcón, Gilberto

Journal or Book Title: Experimental and Molecular Pathology

Keywords: Idiopathic dilated cardiomyopathy; Genetic susceptibility; HLA alleles

Volume/Issue: 82/1

Page Number(s): 49-52

Year Published: 2007


The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC = 0.02, OR = 1.87), HLA-DQB1*0301 (pC = 0.02, OR = 1.92) and HLA-DQB1*0302 (pC = 0.02, OR = 1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC = 0.03, OR = 0.26) and HLA-DQB1*0201 (pC = 0.04, OR = 0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.

DOI: 10.1016/j.yexmp.2006.10.002

Type of Publication: Journal Article