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Cancer Genomics: Data, Data and more Data

Fri, 04/17/2015 - 2:00pm

PLOS Medicine’s Senior Research Editor, Clare Garvey, recently caught up with Francis Ouellette, the Associate Director of Informatics and Biocomputing at the Ontario Institute for Cancer Research (OICR) to find out about progress in cancer genomics, the issues surrounding the … Continue reading »

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Rifts and Bright Spots in Evidence-Based Medicine

Fri, 04/17/2015 - 8:00am

It all starts and ends with the patient. That was a strong message from the first day of Evidence Live. Trisha Greenhalgh walked that walk on day 2. She showed the limits of evidence-based medicine (EBM) with the story of one patient’s … Continue reading »

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Concussion, TBI, human evolution, Neanderthal DNA, blogging news

Thu, 04/16/2015 - 11:17pm

Concussion, traumatic brain injury, and life’s hard knocks Search “concussion” in the media and you’ll come away thinking hard knocks to the head are chiefly a problem for kids and football players (or kid football players.) Last fall the blog … Continue reading »

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Assessing Breast Cancer Risk: Beyond the Angelina Effect

Thu, 04/16/2015 - 3:05pm

On April 30 at 7:30 PM,  I’ll be part of a panel on Health Link with Benita Zahn, WMHT TV, to discuss the genetics behind the “Angelina Jolie effect” that has catalyzed testing for the BRCA mutations that increase risk for breast … Continue reading »

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Head Rattling Results: Fin Whales Hear with Their Skulls

Thu, 04/16/2015 - 1:23pm

Many of us have heard the haunting call of a whale ‘song,’ but how do the whales themselves hear sound? Similar to the way that animals see color in different ranges of the visible light spectrum, the mechanism by which … Continue reading »

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Ask our authors anything: new PLOS ‘AMA’ series debuts on redditscience

Wed, 04/15/2015 - 12:51pm

PLOS, in conjunction with reddit, is pleased to announce the April 22 launch of ‘PLOS Science Wednesday’ a weekly Ask Me Anything (AMA) series featuring PLOS authors in live chats on redditscience (/r/science), the popular online gathering place for researchers, students and others interested in … Continue reading »

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Sordid tale of a study of cognitive behavioral therapy for schizophrenia gone bad

Tue, 04/14/2015 - 8:51am

What motivates someone to publish that paper without checking it? Laziness? Naivety? Greed? Now that’s one to ponder. – Neuroskeptic, Science needs vigilantes. We need to Make the world safe for post-publication peer review (PPR) commentary. Ensure appropriate rewards for … Continue reading »

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Evidence Live and Kicking (Part 1)

Tue, 04/14/2015 - 4:00am

“Evidence based medicine: a movement in crisis?” That 2014 editorial by Trisha Greenhalgh and colleagues echoed through the hallways leading up to this year’s Evidence Live conference, on now at Oxford University. Day 1 down, and the question is well … Continue reading »

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When Open Access is the norm, how do scientists work together online?

Sun, 04/12/2015 - 10:00pm

The Web was invented to enable scientists to collaborate. In 2000 the Los Alamos National Laboratory commissioned me to write a progress report on web-based collaboration between scientists, Internet Groupware for Scientific Collaboration. Blogs, social media, and Open Access publishing of … Continue reading »

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Child Cancer Care and Hospital Hygiene – Can We Have One without the Other?

Fri, 04/10/2015 - 4:53pm

Jocalyn Clark (@JocalynClark) describes the challenge of achieving and maintaining basic cleanliness and sanitation in a children’s cancer ward in Dhaka, Bangladesh. A couple of years ago I wrote about a talk Wendy Graham gave at the Maternal Health conference … Continue reading »

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Alzheimer’s disease update: gloomy

Fri, 04/10/2015 - 12:46pm

The great plague is coming The lede on Joel Shurkin’s three-part post on Alzheimer’s disease and other dementias at Inside Science is stark and discouraging: “The great plague is coming. After 100 years of research and billions of dollars spent … Continue reading »

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Tumor evolution and microbial forensics: the PLOS Comp Biol March Issue

Fri, 04/10/2015 - 11:04am

Here are some highlights from March’s PLOS Computational Biology   Spatial Heterogeneity in Drug Concentrations Acquired resistance is one of the major barriers to successful cancer therapy. There is increasing evidence that the tumor microenvironment influences cell sensitivity to drugs … Continue reading »

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Testing Made Awesome with Docker

Fri, 04/10/2015 - 4:00am

As PLOS has grown (in users, articles, and developers) we have put a lot of effort into splitting our original applications into groups of services. My team is responsible for several web services. We have worked on finding open source … Continue reading »

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Deep Reads: Daisy Hessenberger’s evolving perspective on Gerald Durrell’s books

Thu, 04/09/2015 - 12:27pm

Our third Deep Reads blog post, ‘Deep Reads: Daisy Hessenberger’s evolving perspective on Gerald Durrell’s books’, was written by Daisy Hessenberger, who has recently completed her PhD at the University of Cambridge. Her main scientific interest has always been evolution, … Continue reading »

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Training the Next Generation of Scientists from Disease Endemic Countries Should be a High Priority in Disease Elimination Efforts

Wed, 04/08/2015 - 7:06pm

Serap Aksoy, co-Editor in Chief of PLOS NTDs, comments on the importance of training young scientists in the Tropical Infectious Disease community. There is a lot of excitement in the NTD community around the “E” words. After the many investments made by … Continue reading »

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An ‘apple a day’ keeps the prescription medications away?

Tue, 04/07/2015 - 11:27am

  Last week, a research article titled “Association between apple consumption and physician visits: appealing the conventional wisdom than an apple a day keeps the doctor away” was published online in the journal JAMA Internal Medicine. A great premise for … Continue reading »

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Exercise Physiologist Wanted

Tue, 04/07/2015 - 8:00am

The University of Prince Edward Island is currently looking for an exercise physiologist to join the Kinesiology program in the Department of Applied Human Sciences. From the posting: Candidates must have a doctoral degree in Kinesiology or related field, with … Continue reading »

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Brontosaurus thunders back!

Tue, 04/07/2015 - 7:00am

Pretty much every person who ever read a dinosaur book or went to a natural history museum learned that Brontosaurus is just an outdated name for a big long-necked dinosaur that should be called Apatosaurus. Two different names were applied to the … Continue reading »

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More herbal supplement regulation? Plus scientific April Foolery

Fri, 04/03/2015 - 2:11pm

REGULATION OF HERBAL SUPPLEMENTS IS A SCAM. BUT YOU KNEW THAT. Steven Novella reports at Neurologica on a nice piece of investigative science journalism about government (non)regulation of the supplement industry at the Canadian Broadcasting Corporation. CBC researchers created a … Continue reading »

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Leroy Stevens: Fairwell to The Unsung Hero of Stem Cell Research

Thu, 04/02/2015 - 10:34am

Yesterday a Google Alert popped up with a blast from my past, an obituary for Jackson Lab researcher Leroy C. Stevens. It quoted me calling him “The unsung hero of stem cell research” in an article I wrote 15 years ago … Continue reading »

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